Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511669 | 0.77 | NAPRT (0.44) | KDM4EALDH1A1MEN1KDM6BKDM4A | |
| SCHEMBL30518664 | 0.74 | GAA (0.47) | HCAR2KDM4EALDH1A1MEN1KDM6B | |
| SCHEMBL5517164 | 0.74 | GAA (0.47) | HCAR2KDM4EALDH1A1MEN1KDM6B | |
| SCHEMBL17460006 | 0.73 | NPSR1 (0.47) | HCAR2HSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL11512104 | 0.73 | NPSR1 (0.42) | HSD17B10ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL11278037 | 0.71 | NPSR1 (0.44) | HCAR2HSD17B10KDM4EALDH1A1MEN1 | |
| SCHEMBL27531641 | 0.70 | — | — | |
| SCHEMBL27706995 | 0.69 | FDFT1 (0.33) | KDM4EALDH1A1 | |
| SCHEMBL4103979 | 0.69 | NPSR1 (0.56) | HSD17B10ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL27810412 | 0.68 | HCAR2 (0.44) | HCAR2KDM4EALDH1A1MEN1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689664-A | The quinoline and azepine quinoline compound that tricyclic heteroaryl as PAR4 inhibitor replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | claimed |
| CN-109689664-A | The quinoline and azepine quinoline compound that tricyclic heteroaryl as PAR4 inhibitor replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109689647-A | The compound that bicyclic heteroaryl replaces | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-107428719-A | 4-methylsulfonyl substituted piperidine urea compounds for the treatment of Dilated Cardiomyopathy (DCM) | 迈奥卡迪亚公司 | 2017-12-01 | — | — | CN | disclosed |