Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115684 | 0.80 | ABL1 (0.62) | SYKEPHB4PRKCDABL1BCR | |
| SCHEMBL30213680 | 0.80 | ROCK1 (0.49) | SYKEGFRGAKEPHB4AURKA | |
| SCHEMBL15522255 | 0.80 | ROCK1 (0.49) | SYKEGFRGAKEPHB4AURKA | |
| SCHEMBL22627074 | 0.80 | ABCG2 (0.51) | SYKEGFRGAKIDO1TDO2 | |
| SCHEMBL30847380 | 0.78 | CDK2 (0.55) | SYKEGFREPHB4AURKAPRKCD | |
| SCHEMBL27111928 | 0.78 | CDK2 (0.55) | SYKEGFREPHB4AURKAPRKCD | |
| SCHEMBL3439832 | 0.77 | SYK (0.64) | SYKAURKAPRKCDABL1BCR | |
| SCHEMBL857880 | 0.76 | AURKA (0.70) | EGFREPHB4AURKAPRKCDABL1 | |
| SCHEMBL14368039 | 0.74 | CDK5 (0.53) | SYKEGFRAURKAIDO1PRKCD | |
| SCHEMBL2113984 | 0.74 | AURKA (0.77) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109516959-A | 2- fragrant amino -4- substituted uracil derivative and its application in preparation of anti-tumor drugs | 陕西师范大学 | 2019-03-26 | — | — | CN | disclosed |