Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imatinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 known ✓ | P00519 | 20/20 | 0.93 |
| ▸ | BCR known ✓ | P11274 | 14/20 | 0.93 |
| ▸ | KIT known ✓ | P10721 | 12/20 | 0.93 |
| ▸ | PDGFRB known ✓ | P09619 | 2/20 | 0.88 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.93 |
| ▸ | RAD52 | P43351 | 1/20 | 0.93 |
| ▸ | ABL2 | P42684 | 7/20 | 0.88 |
| ▸ | LYN | P07948 | 3/20 | 0.88 |
| ▸ | SRC | P12931 | 2/20 | 0.88 |
| ▸ | SYK | P43405 | 2/20 | 0.88 |
| ▸ | PLK4 | O00444 | 1/20 | 0.88 |
| ▸ | DDX3X | O00571 | 1/20 | 0.88 |
| ▸ | GAK | O14976 | 1/20 | 0.88 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.88 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.88 |
| ▸ | CA12 | O43570 | 1/20 | 0.88 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.88 |
| ▸ | EGFR | P00533 | 1/20 | 0.88 |
| ▸ | CA1 | P00915 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imatinib SCHEMBL1439360 | 0.97 | ABL1 (0.99) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL1060852 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL8217 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL29377238 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL15632914 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL29370699 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL726190 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL1673189 | 0.97 | ABL1 (1.00) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL1440465 | 0.96 | ABL1 (0.99) | ABL1BCRKITPDGFRARAD52 | |
| Imatinib SCHEMBL5004429 | 0.95 | ABL1 (0.97) | ABL1BCRKITPDGFRARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081443-A2 | DOSAGE FORMS OF TYROSINE KINASE INHIBITORS | ZENTIVA, K.S. (CZ) | 2010-07-22 | — | — | WO | disclosed |