Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ZDHHC20 | Q5W0Z9 | 2/20 | 0.45 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28290627 | 0.98 | CA12 (0.48) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL30433952 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL11061986 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL30433622 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL25277659 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL25225533 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL11264739 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL25225607 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL6426409 | 0.96 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 | |
| SCHEMBL25223124 | 0.94 | CA12 (0.50) | CA12CA1CA9CA2ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109705835-A | A kind of halophilic viscoelastic surfactant clean fracturing fluid and preparation method thereof | 中国石油大学(华东) | 2019-05-03 | — | — | CN | disclosed |