Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Malonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.79 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malonic Acid SCHEMBL29456949 | 0.89 | CA4 (1.00) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL107285 | 0.89 | — | — | |
| Malonic Acid SCHEMBL28920109 | 0.87 | CA4 (0.59) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL28854452 | 0.85 | CA4 (0.92) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL28253669 | 0.85 | CA4 (0.92) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL28315716 | 0.85 | — | — | |
| Malonic Acid SCHEMBL106339 | 0.85 | — | — | |
| Malonic Acid SCHEMBL11307221 | 0.85 | CA4 (0.92) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL10594878 | 0.85 | CA4 (0.92) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL11136925 | 0.85 | CA4 (0.92) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114660896-B | Composition for forming silicon-containing resist underlayer film, pattern forming method, and silicon compound | 信越化学工业株式会社 | 2024-06-11 | — | — | CN | disclosed |
| CN-109593032-A | A kind of co-production of malonic acid and sodium oxalate | 山西凯力德精细化学品科技有限公司 | 2019-04-09 | — | — | CN | disclosed |