Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.63 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CETP | P11597 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29272418 | 0.87 | EP300 (0.52) | EPHX2EP300CETPSOAT1 | |
| SCHEMBL31032253 | 0.87 | EP300 (0.52) | EPHX2EP300CETPSOAT1 | |
| SCHEMBL19665963 | 0.83 | EP300 (0.49) | EPHX2EP300CETPSOAT1 | |
| SCHEMBL7580934 | 0.82 | CETP (0.48) | EPHX2EP300ALDH1A1KDM4ECETP | |
| SCHEMBL22923582 | 0.80 | EP300 (0.51) | EP300CETPSOAT1POLB | |
| SCHEMBL4133118 | 0.79 | POLB (0.58) | EP300CETPSOAT1POLBTP53 | |
| SCHEMBL10115228 | 0.78 | HDAC3 (0.47) | EPHX2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL29480017 | 0.78 | EP300 (0.42) | EPHX2EP300ALDH1A1KDM4ECETP | |
| SCHEMBL4138124 | 0.78 | CETP (0.67) | EP300ALDH1A1CETPSOAT1 | |
| SCHEMBL2618087 | 0.78 | HDAC1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641912-B | Bicyclic heteroaryl derivatives | 豪夫迈·罗氏有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-109641912-A | Bicyclic heteroaryl derivatives | 豪夫迈·罗氏有限公司 | 2019-04-16 | — | — | CN | disclosed |