Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27224565 | 0.85 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL20805209 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL19994399 | 0.84 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL4097866 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL839625 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL3699546 | 0.82 | MAPT (0.64) | SMN1; SMN2RAB9ANPC1MAPTPOLB | |
| SCHEMBL14706944 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL5335117 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL1358356 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1MAPTTSHR | |
| SCHEMBL838537 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715623-A | 5- [2- (pyridin-2-ylamino) -1, 3-thiazol-5-yl ] -2, 3-dihydro-1H-isoindol-1-one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta and gamma | 阿斯利康(瑞典)有限公司 | 2019-05-03 | — | — | CN | disclosed |