Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13475423 | 1.00 | KMT2A (0.67) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL2829307 | 1.00 | KMT2A (0.67) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL265193 | 0.88 | NPC1 (0.59) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL265194 | 0.88 | NPC1 (0.59) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL12218076 | 0.82 | MAPT (0.73) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL11974395 | 0.82 | HDAC3 (0.54) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 | |
| SCHEMBL21916924 | 0.81 | MAPT (0.61) | KMT2ANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL267106 | 0.80 | KMT2A (0.65) | KMT2ANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL267105 | 0.80 | KMT2A (0.65) | KMT2ANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL21145752 | 0.80 | CYP1A2 (0.56) | KMT2ANPC1RAB9ASMN1; SMN2CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | claimed |
| EP-1751553-B1 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-10-08 | — | — | EP | claimed |
| EP-1751553-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | Ludwig-Maximilians-Universität München (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005116640-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | LUDWIG-MAXIMILIANS- UNIVERSITÄT MÜNCHEN (DE) | 2005-12-08 | — | — | WO | claimed |
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-1751553-B1 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | UNIV MUENCHEN L MAXIMILIANS (DE) | 2008-10-08 | — | — | EP | disclosed |
| EP-1751553-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | Ludwig-Maximilians-Universität München (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005116640-A2 | IDENTIFICATION OF ANTI-PRION DRUGS BY HIGH-THROUGHPUT SCREENING BASED ON SIFT | LUDWIG-MAXIMILIANS- UNIVERSITÄT MÜNCHEN (DE) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | PRNP, MAPT, HTT | KMT2A 2872/4885NPC1 337/4885RAB9A 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.