Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.54 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.54 |
| ▸ | NEK2 | P51955 | 2/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.54 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PIR | O00625 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298372 | 0.90 | BRAF (0.65) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL298378 | 0.88 | CYP3A4 (0.66) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL855809 | 0.88 | BRAF (0.62) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL297325 | 0.87 | CYP3A4 (0.62) | BRAFCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL29796856 | 0.86 | BRAF (0.74) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL298039 | 0.86 | BRAF (0.74) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL413713 | 0.86 | BRAF (0.60) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL298432 | 0.86 | CYP3A4 (0.61) | BRAFCYP3A4CYP2C19CYP2C9RIPK2 | |
| SCHEMBL14620763 | 0.86 | CYP3A4 (0.61) | BRAFCYP3A4CYP2C19CYP2C9CYP2D6 | |
| SCHEMBL859195 | 0.85 | BRAF (0.69) | BRAFCYP3A4CYP2C19CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109608450-A | The synthesis of pyrrolo- [2,3-B] pyridine | 普莱希科公司 | 2019-04-12 | — | — | CN | disclosed |