Thiophene

Thiophene

SCHEMBL28293930

CCCCCc1csnn1.c1ccsc1

nearest known ligand 0.41

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Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.41
CYP19A1 P11511 6/20 0.33
MIF P14174 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
MGLL Q99685 2/20 0.30
GPR84 Q9NQS5 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5602872 0.89 KCNH2 (0.44) KCNH2CYP19A1MIFTDP1L3MBTL1
SCHEMBL10385763 0.88 KCNH2 (0.47) KCNH2CYP19A1MIFALDH1A1MGLL
SCHEMBL27948896 0.88 KCNH2 (0.47) KCNH2CYP19A1MIFALDH1A1MGLL
SCHEMBL27948903 0.88 KCNH2 (0.47) KCNH2CYP19A1MIFALDH1A1MGLL
SCHEMBL27918673 0.84
Hexane SCHEMBL3859675 0.71 TSHR (0.44) KCNH2ALDH1A1
SCHEMBL4722131 0.69
Tridecane SCHEMBL23248609 0.69 TSHR (0.50) KCNH2ALDH1A1
Dodecane SCHEMBL789546 0.69 TSHR (0.50) KCNH2ALDH1A1
Octane SCHEMBL1276485 0.69 TSHR (0.50) KCNH2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715696-A Fused thiophene-aryl thiadiazoles polymer, method of the manufacture polymer and application thereof 康宁股份有限公司 2019-05-03 CN disclosed
CN-109715696-A Fused thiophene-aryl thiadiazoles polymer, method of the manufacture polymer and application thereof 康宁股份有限公司 2019-05-03 CN disclosed