Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Kresoxim-Methyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Kresoxim-Methyl SCHEMBL29356012 | 0.98 | HIF1A (0.64) | HIF1ASGMS2MAPTTDP1RXRA | |
| Kresoxym-Methyl SCHEMBL12920836 | 0.98 | HIF1A (0.64) | HIF1ASGMS2MAPTTDP1RXRA | |
| Kresoxim-Methyl SCHEMBL18664 | 0.98 | HIF1A (0.64) | HIF1ASGMS2MAPTTDP1RXRA | |
| Kresoxim-Methyl SCHEMBL54636 | 0.98 | HIF1A (0.64) | HIF1ASGMS2MAPTTDP1RXRA | |
| Kresoxim-Methyl SCHEMBL6102704 | 0.96 | HIF1A (0.63) | HIF1ASGMS2MAPTTDP1RXRA | |
| Kresoxim-Methyl SCHEMBL28193595 | 0.92 | HIF1A (0.58) | HIF1APTGDR2SGMS2MAPTTDP1 | |
| SCHEMBL8521851 | 0.91 | HIF1A (0.53) | HIF1AMAPTTDP1RXRARXRB | |
| SCHEMBL9517991 | 0.88 | HIF1A (0.58) | HIF1APTGDR2SGMS2 | |
| SCHEMBL9026056 | 0.87 | HIF1A (0.48) | HIF1APTGDR2SGMS2MAPTTDP1 | |
| SCHEMBL12920832 | 0.87 | HIF1A (0.48) | HIF1APTGDR2SGMS2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109730068-A | (Z) -2- cyano -3- amino -3- phenyl acrylates compounds inhibit the application of Cereal mycotoxin pollution | 江苏省农药研究所股份有限公司 | 2019-05-10 | — | — | CN | disclosed |