Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.67 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | ITK | Q08881 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 7/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | STK25 | O00506 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.54 |
| ▸ | MUSK | O15146 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656977 | 0.91 | SYK (0.69) | SYKEGFRITKAURKABMPR1B | |
| SCHEMBL12726126 | 0.88 | SYK (0.70) | SYKEGFRITKAURKABMPR1B | |
| SCHEMBL12726123 | 0.85 | SYK (0.74) | SYKEGFRITKAURKAPLK4 | |
| SCHEMBL656063 | 0.85 | EGFR (0.69) | SYKEGFRITKAURKAULK1 | |
| SCHEMBL656345 | 0.84 | SYK (0.74) | SYKEGFRITKAURKA | |
| SCHEMBL657779 | 0.84 | SYK (0.78) | SYKEGFRITKAURKABMPR1B | |
| SCHEMBL12894667 | 0.82 | SYK (0.62) | SYKEGFRITKAURKABMPR1B | |
| SCHEMBL24728127 | 0.82 | SYK (0.62) | SYKEGFRITKAURKABMPR1B | |
| SCHEMBL1221693 | 0.82 | SYK (0.64) | SYKEGFRITKAURKACDC7 | |
| SCHEMBL2100643 | 0.81 | BCL6 (0.72) | SYKAURKASTK17BEPHB4STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017159-B | Fluoro- 2,4- disubstituted amido pyrimidine derivatives of 5- and its preparation method and application | 四川大学 | 2019-05-17 | — | — | CN | disclosed |