SCHEMBL28294633

SCHEMBL28294633

Cc1cc(C)cc(C(N)=Nc2ccccc2)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.70
HIF1A Q16665 1/20 0.70
KMT2A Q03164 2/20 0.64
MEN1 O00255 1/20 0.64
NOS1 P29475 8/20 0.52
NOS3 P29474 4/20 0.52
HTR3E A5X5Y0 5/20 0.48
HTR3B O95264 5/20 0.48
HTR3A P46098 5/20 0.48
HTR3D Q70Z44 5/20 0.48
HTR3C Q8WXA8 5/20 0.48
SLC22A2 O15244 2/20 0.48
SLC22A1 O15245 2/20 0.48
SLC22A3 O75751 2/20 0.48
PLAU P00749 2/20 0.48
LMNA P02545 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
ALOX15 P16050 1/20 0.42
NFKB1 P19838 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11774159 0.85 CYP2D6 (0.66) CYP2D6HIF1AKMT2AMEN1NOS1
SCHEMBL11774153 0.85 CYP2D6 (0.66) CYP2D6HIF1AKMT2AMEN1NOS1
Hydrochloric Acid SCHEMBL11769765 0.84 CYP2D6 (0.64) CYP2D6HIF1AKMT2AMEN1NOS1
Hydrochloric Acid SCHEMBL11769769 0.84 CYP2D6 (0.64) CYP2D6HIF1AKMT2AMEN1NOS1
Hydrochloric Acid SCHEMBL11770106 0.83 CYP2D6 (0.62) CYP2D6HIF1AKMT2AMEN1NOS1
SCHEMBL12463808 0.82 CYP2D6 (1.00) CYP2D6HIF1AKMT2AMEN1NOS1
SCHEMBL28873290 0.82 CYP2D6 (1.00) CYP2D6HIF1AKMT2AMEN1NOS1
Hydrochloric Acid SCHEMBL11770986 0.81 CYP2D6 (0.96) CYP2D6HIF1AKMT2AMEN1NOS1
Hydrochloric Acid SCHEMBL11770989 0.81 CYP2D6 (0.96) CYP2D6HIF1AKMT2AMEN1NOS1
SCHEMBL24662980 0.79 KMT2A (1.00) CYP2D6HIF1AKMT2AMEN1NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109796372-A A method of preparing polysubstituted alkenyl amidine 中国科学院化学研究所 2019-05-24 CN disclosed