Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742403 | 0.85 | HDAC4 (0.46) | HDAC4BACE1FTOHSD11B1 | |
| SCHEMBL17222227 | 0.83 | BACE1 (0.39) | HDAC4AKR1C1BACE1AKR1B1KAT6A | |
| SCHEMBL17222226 | 0.83 | BACE1 (0.39) | HDAC4AKR1C1BACE1AKR1B1KAT6A | |
| SCHEMBL19469486 | 0.82 | HDAC4 (0.62) | HDAC4AKR1C1FTOMEN1KMT2A | |
| SCHEMBL30501932 | 0.82 | HDAC4 (0.62) | HDAC4AKR1C1FTOMEN1KMT2A | |
| SCHEMBL31045853 | 0.79 | APP (0.48) | HDAC4AKR1C1MEN1KMT2AAPP | |
| SCHEMBL16111708 | 0.79 | HDAC4 (0.69) | HDAC4AKR1C1MEN1KMT2A | |
| SCHEMBL15776523 | 0.78 | NCOA1 (0.41) | HDAC4BACE1 | |
| SCHEMBL20242085 | 0.77 | HDAC4 (0.61) | HDAC4AKR1C1APPCYP3A4CYP2C9 | |
| SCHEMBL30790659 | 0.77 | HDAC4 (0.59) | HDAC4AKR1C1FTOMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106957285-B | Amino New cyclobutane derivative, preparation method and its purposes as drug | 皮埃尔法布雷医药公司 | 2019-05-03 | — | — | CN | disclosed |