Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 5/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 4/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829689 | 0.95 | PDE4B (0.93) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2825648 | 0.95 | PDE4B (1.00) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823469 | 0.93 | PDE4B (0.96) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823620 | 0.92 | PDE4B (1.00) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823245 | 0.91 | PDE4B (0.88) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2825093 | 0.90 | PDE4B (1.00) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823487 | 0.90 | PDE4B (0.85) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2826093 | 0.89 | PDE4B (0.87) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2826115 | 0.89 | PDE4B (0.95) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2825813 | 0.89 | PDE4B (0.84) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | claimed |
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |