SCHEMBL28295527

SCHEMBL28295527

CCOC(=O)c1nc(-c2ccc(Cl)cc2)oc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 7/20 1.00
PDCD4 Q53EL6 1/20 0.74
HSD17B10 Q99714 5/20 0.59
ALDH1A1 P00352 3/20 0.54
KDM4E B2RXH2 2/20 0.54
HPGD P15428 1/20 0.54
KMT2A Q03164 1/20 0.54
LMNA P02545 1/20 0.52
MAPT P10636 3/20 0.52
TRPM8 Q7Z2W7 1/20 0.52
GABRA2 P47869 2/20 0.51
GABRB2 P47870 2/20 0.51
POLB P06746 2/20 0.49
NPC1 O15118 1/20 0.49
TSHR P16473 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
IKBKB O14920 1/20 0.49
ALPL P05186 1/20 0.47
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4918154 0.89 TARBP2 (1.00) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL18003815 0.88 TARBP2 (0.78) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL17768259 0.87 TARBP2 (0.82) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL7907774 0.87 TARBP2 (0.82) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL18003341 0.86 TARBP2 (0.76) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL11623692 0.86 TARBP2 (0.80) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL28295518 0.86 TARBP2 (1.00) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL28297264 0.86 TARBP2 (1.00) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL16399092 0.86 TARBP2 (0.75) TARBP2PDCD4HSD17B10ALDH1A1KDM4E
SCHEMBL2485336 0.86 TARBP2 (0.94) TARBP2PDCD4HSD17B10ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109810071-A A kind of miRNA biosynthesis inhibitor 中国科学院成都生物研究所 2019-05-28 CN disclosed