Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.52 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.52 |
| ▸ | TP53BP1 | Q12888 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13090050 | 1.00 | KDM4E (0.64) | KDM4ENPC1RAB9AL3MBTL1L3MBTL3 | |
| SCHEMBL13090047 | 0.99 | KDM4E (0.62) | KDM4ENPC1RAB9AL3MBTL1L3MBTL3 | |
| SCHEMBL4378578 | 0.90 | KDM4E (0.64) | KDM4ENPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL13636362 | 0.90 | KDM4E (0.64) | KDM4ENPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL4384269 | 0.89 | KDM4E (0.62) | KDM4ENPC1RAB9AL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4376224 | 0.89 | KDM4E (0.62) | KDM4ENPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL13636004 | 0.89 | KDM4E (0.62) | KDM4ENPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3767553 | 0.82 | KDM4E (0.54) | KDM4ENPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3767551 | 0.82 | KDM4E (0.54) | KDM4ENPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL29738487 | 0.77 | KDM4E (0.62) | KDM4ENPC1RAB9AL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |