Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558842 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL30602587 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL28940535 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL11836144 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL4942744 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL28681046 | 0.98 | MEN1 (0.47) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL30279573 | 0.92 | CYP1A2 (0.50) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL17868089 | 0.87 | CHUK (0.48) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL29032693 | 0.87 | CHRM2 (0.43) | MEN1NR1I2LMNACHRM2CYP3A4 | |
| SCHEMBL28224526 | 0.87 | CHRM2 (0.43) | MEN1NR1I2LMNACHRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117778533-B | Quantitative detection method for nucleic acid in nucleic acid lipid nanoparticle complex | 北京剂泰医药科技有限公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-117987412-A | SiRNA for inhibiting STAT3 gene expression | 成都先衍生物技术有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117987413-A | SARNA for targeting CEBPA gene expression and application thereof | 成都先衍生物技术有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117778533-A | Quantitative detection method for nucleic acid in nucleic acid lipid nanoparticle complex | 北京剂泰医药科技有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-109913455-A | A kind of siRNA for capableing for the treatment of cancer | 宜春莲泽生物科技发展有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-106467915-B | SiRNA and its application and the method for inhibiting plk1 gene expression | 苏州瑞博生物技术有限公司 | 2019-06-04 | — | — | CN | disclosed |