Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | VDR | P11473 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829676 | 0.90 | KMT2A (0.61) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL2309688 | 0.85 | MAPT (0.64) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL2311978 | 0.83 | KMT2A (0.58) | KMT2AGAAPOLBKDM4EMAPT | |
| SCHEMBL988322 | 0.82 | MAPT (0.57) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL2309376 | 0.81 | KMT2A (0.70) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL2827210 | 0.81 | KMT2A (0.54) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL4497741 | 0.79 | KMT2A (0.81) | KMT2AGAARAB9APOLBMAPT | |
| SCHEMBL4489544 | 0.75 | KMT2A (0.75) | KMT2AGAARAB9AKDM4EMAPT | |
| SCHEMBL2312607 | 0.73 | GAA (0.61) | KMT2AGAARAB9APOLBKDM4E | |
| SCHEMBL2312088 | 0.73 | GAA (0.61) | KMT2AGAARAB9APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |
| EP-2163541-A1 | Piperazine derivatives for binding and imaging amyloid plaques and their use | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-17 | — | — | EP | disclosed |