Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PREP | P48147 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377454 | 0.92 | HPGD (0.74) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4378943 | 0.91 | HPGD (0.76) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL2829098 | 0.89 | HPGD (0.67) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL24163013 | 0.89 | HPGD (0.97) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4378295 | 0.81 | HPGD (0.70) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4381856 | 0.80 | HPGD (0.69) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL24163544 | 0.77 | HPGD (0.79) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4376257 | 0.77 | CYP1A2 (0.72) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4377859 | 0.76 | CYP1A2 (0.71) | HPGDKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL3456248 | 0.76 | HPGD (0.77) | HPGDKMT2AMEN1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |