Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298497 | 1.00 | PDE4B (0.56) | PDE4BKDM4EMAPTTHRBDPP4 | |
| SCHEMBL31683618 | 0.92 | KDM4E (0.56) | PDE4BKDM4EMAPTTHRBDPP4 | |
| SCHEMBL31158869 | 0.87 | PDE4B (0.57) | PDE4BKDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL29580361 | 0.87 | PDE4B (0.57) | PDE4BKDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL10126283 | 0.87 | PDE4B (0.57) | PDE4BKDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL31158950 | 0.87 | PDE4B (0.57) | PDE4BKDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL20531395 | 0.87 | PDE4B (0.57) | PDE4BKDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL1827362 | 0.86 | PDE4B (0.58) | PDE4BKDM4EMAPTTHRBPOLB | |
| SCHEMBL1828228 | 0.86 | PDE4B (0.58) | PDE4BKDM4EMAPTTHRBPOLB | |
| SCHEMBL1827361 | 0.86 | PDE4B (0.58) | PDE4BKDM4EMAPTTHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715633-A | Dopamine-B-hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109715155-A | blood brain barrier-penetrating agent dopamine- β -hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |