Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetylguanidinium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylguanidinium SCHEMBL28647544 | 0.97 | CRBN (0.52) | CRBNTAS2R38FFAR3LCKFYN | |
| Acetylguanidinium SCHEMBL79062 | 0.92 | — | — | |
| Acetylguanidinium SCHEMBL28322882 | 0.89 | — | — | |
| Acetylguanidinium SCHEMBL27551654 | 0.87 | CRBN (0.48) | CRBNTAS2R38LMNAALOX15BLM | |
| Biguanide SCHEMBL27508171 | 0.86 | FFAR3 (0.44) | CRBNTAS2R38FFAR3LCKFYN | |
| Biguanide SCHEMBL28833765 | 0.86 | FFAR3 (0.44) | CRBNTAS2R38FFAR3LCKFYN | |
| Biguanide SCHEMBL28444535 | 0.86 | FFAR3 (0.44) | CRBNTAS2R38FFAR3LCKFYN | |
| Biguanide SCHEMBL27267801 | 0.86 | FFAR3 (0.44) | CRBNTAS2R38FFAR3LCKFYN | |
| Biguanide SCHEMBL28745920 | 0.83 | FFAR3 (0.41) | CRBNTAS2R38FFAR3LCKFYN | |
| Biguanide SCHEMBL27323407 | 0.83 | FFAR3 (0.41) | CRBNTAS2R38FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109694603-A | Foam fireproof coating | 关西涂料株式会社 | 2019-04-30 | — | — | CN | disclosed |