Toluene

Toluene

SCHEMBL28299175

Cc1ccccc1.O=[N+]([O-])c1cccc([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.66

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Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.66
TDP1 Q9NUW8 6/20 0.57
HSD17B10 Q99714 1/20 0.55
GPR35 Q9HC97 2/20 0.55
ALDH1A1 P00352 5/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HPRT1 P00492 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ACHE P22303 2/20 0.47
POLB P06746 1/20 0.44
LMNA P02545 1/20 0.44
ALOX12 P18054 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL10571858 0.91 TSHR (0.82) TSHRTDP1HSD17B10GPR35ALDH1A1
Toluene SCHEMBL27711754 0.87 HSD17B10 (0.64) TSHRTDP1HSD17B10GPR35ALDH1A1
SCHEMBL118464 0.85 TSHR (0.71) TSHRTDP1HSD17B10GPR35ALDH1A1
SCHEMBL1926046 0.85 TSHR (0.71) TSHRTDP1HSD17B10GPR35ALDH1A1
Toluene SCHEMBL28048143 0.83 TSHR (0.59) TSHRTDP1HSD17B10GPR35ALDH1A1
Methylamine SCHEMBL28414354 0.83 TSHR (0.69) TSHRTDP1HSD17B10GPR35ALDH1A1
SCHEMBL7157905 0.83 TSHR (0.68) TSHRTDP1HSD17B10GPR35ALDH1A1
Fluoride SCHEMBL29099623 0.83 TSHR (0.68) TSHRTDP1HSD17B10GPR35ALDH1A1
SCHEMBL29669769 0.83 TSHR (0.68) TSHRTDP1HSD17B10GPR35ALDH1A1
SCHEMBL7157907 0.83 TSHR (0.68) TSHRTDP1HSD17B10GPR35ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109824521-A Between photoacoustic spectroscopy channel synthetic method 中国工程物理研究院化工材料研究所 2019-05-31 CN claimed
CN-109824521-A Between photoacoustic spectroscopy channel synthetic method 中国工程物理研究院化工材料研究所 2019-05-31 CN disclosed