Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ACR | P10323 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23986310 | 1.00 | MAPT (0.66) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL23986235 | 0.94 | MAPT (0.66) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL28461186 | 0.94 | MAPT (0.66) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL28719287 | 0.93 | MAPT (0.64) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL23986620 | 0.93 | MAPT (0.64) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL23986319 | 0.92 | MAPT (0.62) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL28461009 | 0.92 | MAPT (0.62) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL23986567 | 0.92 | MAPT (0.62) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL28461007 | 0.92 | MAPT (0.62) | MAPTRAB9AL3MBTL1CASP3SENP8 | |
| SCHEMBL6835771 | 0.91 | MAPT (0.79) | MAPTRAB9AL3MBTL1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114262321-A | Bistable light-regulated small-molecule protein degradation agent, preparation method and application | 中国药科大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-109761970-B | Protein targeted degradation chimeric molecule, preparation method and application | 中国药科大学 | 2020-06-09 | — | — | CN | disclosed |
| CN-109761970-A | A kind of targeting proteins degradation chimeric molecule, preparation method and application | 中国药科大学 | 2019-05-17 | — | — | CN | disclosed |