SCHEMBL28301970

SCHEMBL28301970

COCCn1cnc2c(N)nc(N)nc21

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 3/20 0.65
CCNB1 P14635 3/20 0.65
CCNE1 P24864 3/20 0.65
CDK2 P24941 3/20 0.65
HSP90AA1 P07900 1/20 0.51
HSP90AB1 P08238 1/20 0.51
NSD3 Q9BZ95 3/20 0.48
LMNA P02545 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
CNR2 P34972 1/20 0.44
ADORA2A P29274 3/20 0.44
ADORA1 P30542 2/20 0.44
ADORA2B P29275 1/20 0.44
FGFR1 P11362 1/20 0.44
SLC22A6 Q4U2R8 1/20 0.44
HPGD P15428 1/20 0.43
TMIGD3 P0DMS9 1/20 0.42
CYP2C19 P33261 1/20 0.42
NSD2 O96028 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12149529 0.83 CYP2C19 (0.50) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL1377647 0.83 CDK1 (0.76) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL215612 0.82 CDK1 (0.57) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL5507967 0.82 CDK1 (0.57) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL27871148 0.81 CDK1 (0.56) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL27736871 0.81 FGFR1 (0.50) CDK1CCNB1CCNE1CDK2NSD3
SCHEMBL4022228 0.81 CCNE1 (0.68) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL2734810 0.81 FGFR1 (0.59) CDK1CCNB1CCNE1CDK2HSP90AA1
SCHEMBL7165319 0.80 NSD3 (0.71) NSD3LMNASMN1; SMN2ADORA2AADORA1
SCHEMBL3922885 0.80 CDK1 (0.71) CDK1CCNB1CCNE1CDK2HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114149432-A Dual CLK/CDK1 inhibitors for cancer treatment 斯坦福国际研究院 2022-03-08 CN disclosed
CN-109937039-A DUAL CLK/CDK1 INHIBITORS FOR CANCER TREATMENT 斯坦福国际研究院 2019-06-25 CN disclosed