Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desloratadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 15/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.89 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.89 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | HTR1A | P08908 | 1/20 | 0.89 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | DRD2 | P14416 | 1/20 | 0.89 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.89 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.89 |
| ▸ | DRD1 | P21728 | 1/20 | 0.89 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.89 |
| ▸ | DRD4 | P21917 | 1/20 | 0.89 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desloratadine SCHEMBL4425 | 0.94 | HRH1 (1.00) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL29390260 | 0.94 | HRH1 (1.00) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL29371361 | 0.94 | HRH1 (1.00) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL5198706 | 0.93 | HRH1 (0.97) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL5200118 | 0.93 | HRH1 (0.97) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL4574215 | 0.93 | HRH1 (0.97) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL5200429 | 0.93 | HRH1 (0.97) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL5374223 | 0.92 | HRH1 (0.95) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL5378852 | 0.92 | HRH1 (0.95) | HRH1MEN1LMNAADRB2CHRM2 | |
| Desloratadine SCHEMBL28342587 | 0.90 | HRH1 (0.87) | HRH1MEN1LMNAADRB2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109897027-A | A kind of synthetic method of 3- hydroxyl Desloratadine metabolin | 梯尔希（南京）药物研发有限公司 | 2019-06-18 | — | — | CN | disclosed |