SCHEMBL283080

SCHEMBL283080

CCCCCCCCCCCCc1ccc(S(=O)(=O)Nc2nncs2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 14/20 1.00
GAB1 Q13480 3/20 1.00
PDPK1 O15530 1/20 1.00
ABCB11 O95342 1/20 1.00
AKT2 P31751 1/20 1.00
AKT3 Q9Y243 1/20 1.00
IRS1 P35568 1/20 0.59
MEN1 O00255 1/20 0.57
TSHR P16473 1/20 0.57
KMT2A Q03164 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL283200 1.00 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL283518 1.00 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL283309 1.00 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL283155 1.00 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL283219 1.00 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL282536 0.95 AKT1 (1.00) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL11891730 0.89 AKT1 (0.80) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL11891726 0.88 AKT1 (0.78) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL11891720 0.88 AKT1 (0.78) AKT1GAB1PDPK1ABCB11AKT2
SCHEMBL11891682 0.86 AKT1 (0.75) AKT1GAB1PDPK1ABCB11AKT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 610 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075487-A Application of PHT-427 in preparing medicine for inhibiting activity of monkey pox core protease 2026-05-26 CN claimed
EP-4732908-A2 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS Biomed Valley Discoveries, Inc. (US) 2026-04-29 EP claimed
US-20260053785-A1 COMBINATION THERAPY FOR TREATMENT OF CANCER PMV PHARMACEUTICALS INC (US) 2026-02-26 US claimed
EP-4043017-B1 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2026-01-28 EP claimed
EP-3664807-B1 METHODS AND MATERIALS FOR IDENTIFYING AND TREATING BET INHIBITOR-RESISTANT CANCERS MAYO FOUND MEDICAL EDUCATION & RES (US) 2025-11-19 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
EP-4615431-A1 COMBINATION THERAPIES FOR THE TREATMENT OF CANCER Astrazeneca AB (SE) 2025-09-17 EP claimed
EP-4604957-A1 COMBINATIONS OF A SERD FOR THE TREATMENT OF CANCER Astrazeneca AB (SE) 2025-08-27 EP claimed
US-20250205233-A1 EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TYROSINE KINASE INHIBITORS IN COMBINATION WITH AN AKT INHIBITOR FOR THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2025-06-26 US claimed
US-20250171518-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CITY OF HOPE 2025-05-29 US claimed
US-20220235330-A1 METHODS FOR CREATING INTEGRATION-FREE, VIRUS-FREE, EXOGENOUS ONCOGENE-FREE IPS CELLS AND COMPOSITIONS FOR USE IN SUCH METHODS Cellular Engineering Technologies, Inc. (US) 2022-07-28 US claimed
CN-114746093-A Method for treating vascular malformations 德西费拉制药有限责任公司 2022-07-12 CN claimed
EP-4013417-A1 METHODS AND COMPOSITIONS FOR TREATING VASCULAR MALFORMATIONS Deciphera Pharmaceuticals, LLC (US) 2022-06-22 EP claimed
WO-2022093770-A1 COMBINATION THERAPY WITH PI3K-AKT-MTOR INHIBITORS AND FERROPTOSIS INDUCING AGENTS TO TREAT CANCER MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-05-05 WO claimed
EP-3082957-B1 CANCER TREATMENTS USING COMBINATIONS OF PI3K/AKT PATHWAY AND ERK INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2022-04-06 EP claimed
EP-3082800-B1 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2022-02-02 EP claimed
US-20190316095-A1 METHODS FOR CREATING INTEGRATION-FREE, VIRUS-FREE, EXOGENOUS ONCOGENE-FREE IPS CELLS AND COMPOSITIONS FOR USE IN SUCH METHODS Cellular Engineering Technologies, Inc. (US) 2019-10-17 US claimed
US-20180369264-A1 COMBINATION OF A CARDIAC STEROID AND AN AKT INHIBITOR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISORDERS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2018-12-27 US claimed
EP-3393477-A1 COMBINATION OF A CARDIAC STEROID AND AN AKT INHIBITOR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISORDERS Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2018-10-31 EP claimed
WO-2017109778-A1 COMBINATION OF A CARDIAC STEROID AND AN AKT INHIBITOR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISORDERS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2017-06-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260053785-A1 COMBINATION THERAPY FOR TREATMENT OF CANCER TP53, PI4K2A, PIK3CA AKT1 18/4885GAB1 4018/4885PDPK1 100/4885
US-20250171518-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CD4, ICOS, CD2 AKT1 3905/4885GAB1 1040/4885PDPK1 4568/4885
US-20250205233-A1 EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) TYROSINE KINASE INHIBITORS IN COMBINATION WITH AN AKT INHIBITOR FOR THE TREATMENT OF CANCER EGFR, ERBB2, ERBB3 AKT1 21/4885GAB1 454/4885PDPK1 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.