Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831658 | 0.90 | PDE4B (0.79) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2834635 | 0.80 | PDE4B (0.72) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2825965 | 0.79 | PDE4B (0.85) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2825745 | 0.78 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2831980 | 0.78 | PDE4B (0.74) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2821745 | 0.78 | PDE4B (0.98) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2821811 | 0.77 | PDE4B (0.92) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2831991 | 0.77 | PDE4B (0.71) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2826338 | 0.77 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2APDE4A | |
| SCHEMBL2824854 | 0.76 | PDE4B (0.94) | PDE4BADORA1ADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |