Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NT5E | P21589 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054080 | 0.88 | TSHR (0.79) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| SCHEMBL11395010 | 0.87 | TSHR (0.85) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| SCHEMBL1655356 | 0.87 | TSHR (1.00) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| SCHEMBL29044 | 0.87 | TSHR (1.00) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| Aniline SCHEMBL28185301 | 0.85 | TSHR (0.88) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| Ammonia Solution, Strong SCHEMBL3850533 | 0.85 | TSHR (0.96) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| Lithium SCHEMBL31518347 | 0.85 | TSHR (0.96) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| Ammonia Solution, Strong SCHEMBL3850530 | 0.85 | TSHR (0.96) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| SCHEMBL28795398 | 0.85 | TSHR (0.96) | ALDH1A1TSHRTDP1HSD17B10LMNA | |
| Sulfuric Acid SCHEMBL8641555 | 0.85 | TSHR (0.96) | ALDH1A1TSHRTDP1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110028495-B | The preparation method of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-12-03 | — | — | CN | claimed |
| CN-110028495-A | The environment-friendly preparation method thereof of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-07-19 | — | — | CN | claimed |
| CN-110028495-B | The preparation method of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-12-03 | — | — | CN | disclosed |
| CN-110028495-A | The environment-friendly preparation method thereof of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-07-19 | — | — | CN | disclosed |