Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TPMT | P51580 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849364 | 0.91 | CA12 (0.63) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL22279603 | 0.80 | MAPT (0.53) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL8996451 | 0.78 | CA12 (0.74) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL27303132 | 0.78 | CA12 (0.57) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL30805788 | 0.78 | CA12 (0.57) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL582414 | 0.78 | MAPT (0.68) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL14612801 | 0.78 | TDP1 (0.53) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL7718116 | 0.77 | CA12 (0.59) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL9774171 | 0.77 | TPMT (0.55) | MAPTTDP1CA12CA1CA2 | |
| SCHEMBL1323122 | 0.76 | CA12 (0.55) | MAPTTDP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156739-A | The preparation method of 1,3,5,8- tetrahydroxy xanthone and 1,3,7,8- tetrahydroxy xanthone | 广州药本君安医药科技股份有限公司 | 2019-08-23 | — | — | CN | disclosed |