SCHEMBL28313335

SCHEMBL28313335

O=COCc1ccc2cc(Br)ccc2n1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.45
HDAC2 Q92769 6/20 0.45
BACE1 P56817 1/20 0.45
TLR2 O60603 1/20 0.38
CYSLTR1 Q9Y271 3/20 0.34
CYSLTR2 Q9NS75 2/20 0.34
ERN1 O75460 1/20 0.33
CYP3A4 P08684 1/20 0.33
DPP4 P27487 1/20 0.33
GPBAR1 Q8TDU6 1/20 0.33
PDE10A Q9Y233 1/20 0.33
CYP2A6 P11509 1/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
STAT1 P42224 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28838171 0.83 ESR1 (0.44) HDAC1HDAC2CYSLTR1CYSLTR2GPBAR1
SCHEMBL28105775 0.82 HDAC1 (0.36) HDAC1HDAC2CYSLTR1CYSLTR2GPBAR1
SCHEMBL28105295 0.81 CYP1A2 (0.47) BACE1CYSLTR1CYSLTR2CYP2A6MEN1
SCHEMBL28312508 0.81 HDAC1 (0.44) HDAC1HDAC2BACE1CYSLTR1CYSLTR2
SCHEMBL266084 0.79 BACE1 (0.49) HDAC1HDAC2BACE1TLR2ERN1
SCHEMBL16621472 0.79 BACE1 (0.49) HDAC1HDAC2BACE1TLR2CYSLTR1
SCHEMBL30718562 0.79 BACE1 (0.49) HDAC1HDAC2BACE1TLR2CYSLTR1
SCHEMBL7510557 0.77 CYSLTR1 (0.57) CYSLTR1CYSLTR2GPBAR1PDE10A
SCHEMBL27779108 0.76 BACE1 (0.53) HDAC1HDAC2BACE1TLR2CYP2A6
SCHEMBL28313537 0.76 HDAC1 (0.33) HDAC1HDAC2CYSLTR1CYSLTR2PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110156760-A A kind of preparation method of 4- (1,4- dioxane -2- base) quinoline -2- methyl formate derivative 济南大学 2019-08-23 CN disclosed