Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20137489 | 0.84 | RET (0.47) | RETGPR119 | |
| SCHEMBL28315073 | 0.82 | RET (0.39) | RETCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20069623 | 0.82 | RET (0.49) | RETSMOCHRM2CHRM4CHRM5 | |
| SCHEMBL20158526 | 0.81 | RET (0.48) | RETSMOGAA | |
| SCHEMBL20070610 | 0.78 | RET (0.44) | RETSMOCHRM2CHRM4CHRM5 | |
| SCHEMBL27684009 | 0.77 | GAA (0.38) | GAAL3MBTL1SMN1; SMN2GPR119 | |
| Tert-Butyl Formate SCHEMBL28875723 | 0.76 | RET (0.41) | RETCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL27666299 | 0.72 | KDM4E (0.55) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL21651955 | 0.71 | RET (0.49) | RETGAAL3MBTL1 | |
| SCHEMBL28328445 | 0.71 | POLB (0.50) | GAAL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |