SCHEMBL28314768

SCHEMBL28314768

CC(C)(C)C(C(=O)O)(C(=O)O)c1ccccc1.[KH].[LiH]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.47
KMT2A Q03164 1/20 0.47
CYP2C19 P33261 3/20 0.45
HIF1A Q16665 1/20 0.45
CYP1A2 P05177 2/20 0.45
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
CYP2D6 P10635 1/20 0.42
KCNN4 O15554 1/20 0.41
ALDH1A1 P00352 3/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21268875 0.98 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL21269305 0.98 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL28315662 0.96 MAPT (0.47) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL10693921 0.96 MAPT (0.50) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL28315623 0.93 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL28315725 0.93 KMT2A (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL21269792 0.93 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL28315789 0.93 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
Hydrochloric Acid SCHEMBL11304473 0.93 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2
SCHEMBL27533406 0.80 MAPT (0.48) MAPTKMT2ACYP2C19HIF1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110172019-A The metal salt of malonic acid as the nucleating additive for crystalline thermoplastic 印度石油有限公司 2019-08-27 CN disclosed