Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148111 | 0.88 | RET (0.47) | RETCYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL28660592 | 0.81 | CYP1A2 (0.39) | RETCYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL20069291 | 0.79 | MEN1 (0.42) | RETCYP2D6TSHRSMN1; SMN2POLB | |
| SCHEMBL28664232 | 0.76 | SMN1; SMN2 (0.41) | CYP2D6SMN1; SMN2POLBALDH1A1NPC1 | |
| SCHEMBL20070610 | 0.76 | RET (0.44) | RETCYP2D6MAPTSMN1; SMN2POLB | |
| SCHEMBL20069627 | 0.74 | RET (0.52) | RETCYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL25502428 | 0.74 | RET (0.51) | RETCYP1A2CYP2D6MAPTTSHR | |
| SCHEMBL20069388 | 0.73 | TLR2 (0.39) | RETKMT2A | |
| SCHEMBL20070066 | 0.73 | RET (0.47) | RETTSHRPOLBALDH1A1NPC1 | |
| SCHEMBL20137436 | 0.73 | RET (0.51) | RETCYP1A2CYP2D6MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |
| CN-110177786-A | Pyrazolo [1,5-A] pyridine compounds being substituted are as RET kinase inhibitor | 阿雷生物药品公司 | 2019-08-27 | — | — | CN | disclosed |