Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16034537 | 0.87 | MIF (0.39) | HSD11B1HTTMIFALDH1A1 | |
| SCHEMBL14861683 | 0.87 | MIF (0.39) | HSD11B1HTTMIFALDH1A1 | |
| SCHEMBL2477922 | 0.87 | MIF (0.39) | HSD11B1HTTMIFALDH1A1 | |
| SCHEMBL443529 | 0.77 | MIF (0.46) | MIF | |
| SCHEMBL22839887 | 0.73 | MIF (0.35) | MIF | |
| SCHEMBL7190192 | 0.73 | MIF (0.35) | MIF | |
| SCHEMBL22279374 | 0.72 | MIF (0.42) | HTTMIFKDM4EALDH1A1 | |
| SCHEMBL21304587 | 0.72 | MIF (0.42) | HTTMIFKDM4EALDH1A1 | |
| SCHEMBL22279434 | 0.71 | PTGS1 (0.49) | — | |
| SCHEMBL28660955 | 0.71 | PTGS1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267960-A | Substituted pyrazolo [1,5-a] pyrazine compound as RET kinase inhibitor | 阿雷生物药品公司 | 2019-09-20 | — | — | CN | disclosed |