Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.64 |
| ▸ | SCN3A | Q9NY46 | 9/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN4A | P35499 | 1/20 | 0.52 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2831126 | 0.99 | KCNH2 (0.63) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2833100 | 0.90 | KCNH2 (0.62) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| Hydrochloric Acid SCHEMBL2836769 | 0.90 | KCNH2 (0.61) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2831019 | 0.89 | KCNH2 (0.57) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| Hydrochloric Acid SCHEMBL2836673 | 0.88 | KCNH2 (0.56) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2834682 | 0.85 | KCNH2 (0.56) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2837151 | 0.81 | KCNH2 (0.55) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2836240 | 0.81 | KCNH2 (0.55) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2836357 | 0.81 | KCNH2 (0.58) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| Hydrochloric Acid SCHEMBL2833879 | 0.81 | KCNH2 (0.55) | KCNH2SCN3ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | US | claimed |
| EP-2129655-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | Glaxo Group Limited (GB) | 2009-12-09 | — | — | EP | claimed |
| WO-2008122546-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | WO | claimed |
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | US | disclosed |
| EP-2129655-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | Glaxo Group Limited (GB) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008122546-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | SCN1A, SCN3A, SCN2A | KCNH2 22/4885SCN3A 2/4885SCN9A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.