Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622485 | 0.81 | KDM4E (0.55) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL3987986 | 0.81 | KDM4E (0.55) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL5889548 | 0.81 | KDM4E (0.68) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL28264561 | 0.79 | MCL1 (0.53) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL27880258 | 0.79 | KDM4E (0.53) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL28143548 | 0.79 | KDM4E (0.49) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL408368 | 0.78 | KDM4E (0.47) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL3137745 | 0.77 | KDM4E (0.46) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL29951356 | 0.77 | KDM4E (0.46) | HCAR3KDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL16441004 | 0.77 | KDM4E (0.46) | HCAR3KDM4EHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110423212-A | The inhibitor based on oxyindole carboxylic acid of SHP2 | UNIV INDIANA RES & TECH CORP | 2019-11-08 | — | — | CN | disclosed |