Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.73 |
| ▸ | RORC | P51449 | 4/20 | 0.73 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.73 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.71 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.71 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.64 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.61 |
| ▸ | CRYAB | P02511 | 1/20 | 0.61 |
| ▸ | HMGCR | P04035 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.61 |
| ▸ | ITGAV | P06756 | 1/20 | 0.61 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.61 |
| ▸ | POLA1 | P09884 | 1/20 | 0.60 |
| ▸ | DHCR24 | Q15392 | 2/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29276941 | 0.96 | OSBP (0.79) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28154512 | 0.94 | OSBP (0.83) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28494148 | 0.93 | OSBP (0.72) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27873562 | 0.93 | OSBP (0.84) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27611626 | 0.93 | OSBP (0.84) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27639632 | 0.93 | OSBP (0.84) | OSBPRORCOSBP2USP2LMNA | |
| Octacosanol SCHEMBL28595297 | 0.93 | OSBP (0.84) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28637815 | 0.93 | OSBP (0.73) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29729264 | 0.93 | OSBP (0.73) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27962121 | 0.93 | OSBP (0.73) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112266781-A | Thermochromic material composition | 江苏康恒化工有限公司 | 2021-01-26 | — | — | CN | disclosed |
| CN-110306365-A | One kind being based on heat-sensitive variable colour stamp liquid crystal microcapsule preparation method | 苏州夏布朗纺织科技有限公司 | 2019-10-08 | — | — | CN | disclosed |