Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28554727 | 0.86 | TSHR (0.57) | ELANETDP1TSHRMAPK1S1PR1 | |
| SCHEMBL20240716 | 0.86 | TDP1 (0.59) | ELANETDP1TSHRMAPK1LMNA | |
| SCHEMBL7192676 | 0.84 | ELANE (0.58) | ELANETDP1PDE4AKCNH2LMNA | |
| SCHEMBL2970319 | 0.84 | ELANE (0.52) | ELANETDP1TSHRMAPK1MAOB | |
| SCHEMBL29705186 | 0.84 | ELANE (0.52) | ELANETDP1TSHRMAPK1MAOB | |
| SCHEMBL7185413 | 0.83 | PDE4A (0.65) | ELANETDP1TSHRMAPK1PDE4A | |
| SCHEMBL7953666 | 0.82 | ELANE (0.58) | ELANETDP1TSHRMAPK1MAOB | |
| SCHEMBL7179542 | 0.82 | PDE4A (0.55) | ELANETDP1MAPK1CLEC4MPDE4A | |
| SCHEMBL7175985 | 0.82 | ELANE (0.50) | ELANETDP1MAPK1MAOBPDE4A | |
| SCHEMBL30495379 | 0.82 | S1PR1 (0.47) | ELANES1PR1S1PR3PDE4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116406365-A | Process for the preparation of 1-methyl-6- [ 6-R2-5-methyl-8- (methylamino) -4- [ (3 aS,6 aS) -5-methyl-2, 3a,4,6 a-hexahydropyrrolo [2,3-c ] pyrrol-1-yl ] -9H-pyrido [2,3-b ] indol-3-yl ] -4-oxo-1, 8-naphthyridine-3-carboxylic acid hydrochloride | 豪夫迈·罗氏有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-113166174-A | Free amino compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-112752762-A | Substituted pyridoindoles for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-110475777-A | For treating and preventing new pyrido [2,3-b] benzazolyl compounds of bacterium infection | HOFFMANN LA ROCHE | 2019-11-19 | — | — | CN | disclosed |