Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ITGAL | P20701 | 4/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377227 | 0.92 | HPGD (0.47) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL13636365 | 0.92 | HPGD (0.47) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL4382018 | 0.91 | HCAR2 (0.48) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL14190928 | 0.91 | HCAR2 (0.48) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL13090095 | 0.88 | HPGD (0.51) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL2831501 | 0.85 | HPGD (0.61) | HPGDKDM4EALDH1A1KMT2ANPC1 | |
| SCHEMBL3765820 | 0.84 | ITGB2 (0.42) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL3765817 | 0.84 | ITGB2 (0.42) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL7619374 | 0.81 | ITGAL (0.77) | HPGDITGALITGB2ICAM1KDM4E | |
| SCHEMBL6308792 | 0.81 | ITGAL (0.77) | HPGDITGALITGB2ICAM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |