Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22369392 | 0.88 | CHEK1 (0.41) | MKNK1MAPK1MAPK3CHEK1MAP2K4 | |
| SCHEMBL20931536 | 0.85 | MAP2K4 (0.46) | MKNK1MAPK1MAPK3CHEK1MAP2K4 | |
| SCHEMBL30554310 | 0.85 | MAP2K4 (0.46) | MKNK1MAPK1MAPK3CHEK1MAP2K4 | |
| SCHEMBL20916861 | 0.84 | MAPK1 (0.48) | MKNK1MAPK1MAPK3CHEK1 | |
| SCHEMBL20917257 | 0.84 | MAPK1 (0.48) | MKNK1MAPK1MAPK3CHEK1 | |
| SCHEMBL22299598 | 0.82 | PKN1 (0.51) | MAPK1 | |
| SCHEMBL20932327 | 0.82 | MKNK1 (0.42) | MKNK1MAPK1MAPK3CHEK1PIM1 | |
| SCHEMBL22299386 | 0.82 | MAPK1 (0.43) | MKNK1MAPK1MAPK3CHEK1 | |
| SCHEMBL20916971 | 0.82 | MAPK1 (0.43) | MKNK1MAPK1MAPK3CHEK1 | |
| SCHEMBL20916970 | 0.82 | MAPK1 (0.43) | MKNK1MAPK1MAPK3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-110546150-B | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-112020357-A | Salts of indazolyl-containing tricyclic derivatives and crystal forms thereof | 上海翰森生物医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-110546150-A | Pyrazolyl-containing tricyclic derivatives, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-12-06 | — | — | CN | disclosed |