Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28334986 | 0.92 | GAA (0.42) | NPC1GAABRD4CTSVCTSL | |
| SCHEMBL18787255 | 0.82 | NPC1 (0.43) | NPC1GAABRD4CTSVCTSL | |
| SCHEMBL30437072 | 0.82 | NPC1 (0.43) | NPC1GAABRD4CTSVCTSL | |
| SCHEMBL29564439 | 0.79 | MEN1 (0.44) | NPC1GAABRD4MAPK1MAPT | |
| SCHEMBL17258686 | 0.79 | MEN1 (0.44) | NPC1GAABRD4MAPK1MAPT | |
| SCHEMBL18787256 | 0.77 | KDM1A (0.45) | NPC1BRD4MAPK1MAPTTDP1 | |
| SCHEMBL28332769 | 0.76 | KDM1A (0.44) | NPC1BRD4MAPK1MAPTTDP1 | |
| SCHEMBL23663364 | 0.73 | FFAR1 (0.47) | NPC1GAABRD4CTSVCTSL | |
| SCHEMBL29703994 | 0.72 | KDM1A (0.48) | NPC1GAAMAPK1MAPTTDP1 | |
| SCHEMBL18787264 | 0.72 | KDM1A (0.48) | NPC1GAAMAPK1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573157-B | Methods of treatment using JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-110603255-B | Crystalline forms of a JAK inhibitor compound | 施万生物制药研发IP有限责任公司 | 2023-02-10 | — | — | CN | disclosed |
| CN-108349972-B | JAK kinase inhibitor compounds for the treatment of respiratory diseases | 施万生物制药研发IP有限责任公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-110603255-A | Crystalline forms of a JAK inhibitor compound | 施万生物制药研发IP有限责任公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-110573157-A | Methods of treatment using JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2019-12-13 | — | — | CN | disclosed |