Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361395 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL180161 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL1275761 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| Acetic Acid SCHEMBL2878826 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL4359977 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL2927672 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL2164933 | 0.77 | PPARG (0.58) | SMN1; SMN2HIF1ASLC6A3HDAC6FFAR1 | |
| SCHEMBL2164934 | 0.77 | PPARG (0.58) | SMN1; SMN2HIF1ASLC6A3HDAC6FFAR1 | |
| SCHEMBL1059557 | 0.77 | SLC6A2 (0.52) | SMN1; SMN2HIF1AMAPK1SLC6A2TAAR1 | |
| SCHEMBL23572607 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2HIF1ASLC6A2TAAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110548173-B | Preparation method of chemoembolization microsphere with microwave sensitization effect | 苏州恒瑞迦俐生生物医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-110548173-A | preparation method of chemoembolization microsphere with microwave sensitization effect | SUZHOU HENGRUI JIALISHENG BIOMEDICINE TECH CO LTD | 2019-12-10 | — | — | CN | disclosed |