Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.60 |
| ▸ | JAK1 | P23458 | 8/20 | 0.59 |
| ▸ | JAK3 | P52333 | 5/20 | 0.59 |
| ▸ | TYK2 | P29597 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13774665 | 0.86 | JAK2 (0.61) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13695723 | 0.84 | JAK2 (0.65) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL20908684 | 0.82 | JAK2 (0.69) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL101195 | 0.82 | JAK2 (0.62) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL27741963 | 0.81 | JAK2 (0.65) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13695724 | 0.81 | JAK2 (0.62) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL101593 | 0.81 | JAK2 (0.62) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL24053067 | 0.80 | JAK2 (0.55) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL10315626 | 0.80 | JAK2 (0.59) | JAK2HDAC6HDAC1JAK1JAK3 | |
| SCHEMBL13695626 | 0.79 | JAK2 (0.66) | JAK2HDAC6HDAC1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137603-B | Azetidine derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2019-10-18 | — | — | CN | disclosed |