Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA4 | P22748 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9617013 | 0.92 | — | — | |
| Acetic Acid SCHEMBL7920770 | 0.83 | CA1 (0.89) | CA1CA4ALOX15ALDH1A1TDP1 | |
| Acetic Acid SCHEMBL28794923 | 0.79 | — | — | |
| Acetic Acid SCHEMBL27894508 | 0.77 | CA1 (0.61) | CA1CA4ALOX15LMNATSHR | |
| Acetic Acid SCHEMBL5013573 | 0.77 | CA1 (0.61) | CA1CA4ALOX15LMNATSHR | |
| Acetic Acid SCHEMBL10427734 | 0.77 | — | — | |
| Bicarbonate SCHEMBL11274973 | 0.75 | — | — | |
| Acetic Acid SCHEMBL9117998 | 0.74 | CA1 (0.89) | CA1CA4ALOX15ALDH1A1TDP1 | |
| Acetic Acid SCHEMBL983612 | 0.74 | CA1 (0.89) | CA1CA4ALOX15ALDH1A1TDP1 | |
| Acetic Acid SCHEMBL140294 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112626061-B | Multienzyme ordered co-immobilization method for improving efficiency of cascade catalytic system | 上海交通大学 | 2021-09-14 | — | — | CN | disclosed |
| CN-112626061-A | Multienzyme ordered co-immobilization method for improving efficiency of cascade catalytic system | 上海交通大学 | 2021-04-09 | — | — | CN | disclosed |
| CN-110637034-A | CXCR2 antibodies and uses thereof | 莫纳什大学 | 2019-12-31 | — | — | CN | disclosed |