Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15507141 | 1.00 | KDM4E (0.48) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL4164966 | 1.00 | KDM4E (0.48) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL16459750 | 1.00 | KDM4E (0.48) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL4164968 | 1.00 | KDM4E (0.48) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL25465736 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL30661567 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL19813102 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL17966350 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL17966352 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 | |
| SCHEMBL17966353 | 0.88 | KDM4E (0.47) | KDM4EPKMGPR119NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612302-B | Pyrazolo [1,5-a ] pyrimidine derivatives as kinase JAK inhibitors | 赛隆制药股份公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-110612302-A | Pyrazolo [1,5-a ] pyrimidine derivatives as kinase JAK inhibitors | 赛隆制药股份公司 | 2019-12-24 | — | — | CN | disclosed |