Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 16/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29859393 | 1.00 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL19631430 | 1.00 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL29859538 | 0.87 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL19631503 | 0.87 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL28346811 | 0.87 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL19631461 | 0.86 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL29859512 | 0.86 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL28343270 | 0.86 | DHODH (1.00) | DHODHKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL25614384 | 0.83 | DHODH (0.71) | DHODHKMT2AALDH1A1LMNAHPGD | |
| SCHEMBL20956565 | 0.79 | DHODH (1.00) | DHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107375279-B | Use of novel thiazole derivatives for the treatment of inflammatory bowel disease | 华东理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-107382902-B | Thiazole derivative and application thereof | 华东理工大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-107459496-B | Use of thiazole derivatives for treating viral infections | 华东理工大学 | 2022-07-19 | — | — | CN | disclosed |
| CN-106892878-B | Thiazole derivative and application thereof in inhibiting dihydroorotate dehydrogenase | 华东理工大学 | 2020-01-10 | — | — | CN | disclosed |