Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 7/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | CLK3 | P49761 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681713 | 0.84 | DDB1 (0.52) | DDB1CRBNIRAK4JAK2JAK3 | |
| SCHEMBL31553946 | 0.84 | HCRTR1 (0.33) | ACHEHCRTR1HCRTR2 | |
| SCHEMBL31260499 | 0.83 | GAA (0.37) | IRAK4CLK2CLK3DYRK1AGSK3B | |
| SCHEMBL27951646 | 0.80 | DDB1 (0.36) | DDB1CRBNACHEIRAK4CLK2 | |
| SCHEMBL28803589 | 0.79 | LRRK2 (0.36) | IRAK4JAK2JAK1JAK3HCRTR1 | |
| SCHEMBL991994 | 0.78 | DDB1 (0.38) | DDB1CRBNACHEIRAK4JAK2 | |
| SCHEMBL320321 | 0.77 | FFAR1 (0.42) | KDM5ADDB1CRBNMAP3K7TAB1 | |
| SCHEMBL31553951 | 0.76 | PIM1 (0.36) | KDM5AHCRTR1HCRTR2 | |
| SCHEMBL17541510 | 0.76 | OGA (0.43) | KDM5ADDB1CRBNMAP3K7TAB1 | |
| SCHEMBL12095709 | 0.75 | HCRTR1 (0.33) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110627770-A | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2019-12-31 | — | — | CN | disclosed |