Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 12/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28598211 | 0.86 | HIF1A (1.00) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28594259 | 0.85 | HIF1A (0.84) | HIF1ANPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28345384 | 0.85 | HIF1A (0.88) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28348077 | 0.84 | HIF1A (0.86) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28344737 | 0.84 | HIF1A (1.00) | HIF1ANPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28603560 | 0.83 | HIF1A (1.00) | HIF1ANPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28347862 | 0.82 | HIF1A (0.83) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28348304 | 0.81 | HIF1A (0.81) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28347976 | 0.81 | HIF1A (0.84) | HIF1ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL28344622 | 0.80 | HIF1A (0.79) | HIF1ANPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110407824-B | Aryl formamide compound and preparation method, pharmaceutical composition and application thereof | 安徽医科大学 | 2021-07-02 | — | — | CN | disclosed |
| CN-110407824-A | Aryl methanamide compounds and preparation method thereof, pharmaceutical composition and purposes | UNIV ANHUI MEDICAL | 2019-11-05 | — | — | CN | disclosed |