⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830475 | 0.92 | — | — | |
| SCHEMBL1954719 | 0.90 | BCL2 (0.74) | — | |
| SCHEMBL2829630 | 0.90 | — | — | |
| SCHEMBL2828999 | 0.88 | BCL2 (0.63) | — | |
| SCHEMBL2830501 | 0.87 | — | — | |
| SCHEMBL19424766 | 0.84 | BCL2 (0.63) | — | |
| SCHEMBL18274762 | 0.84 | BCL2 (0.66) | — | |
| SCHEMBL1957757 | 0.81 | BCL2 (0.78) | — | |
| SCHEMBL1743602 | 0.80 | — | — | |
| SCHEMBL1742960 | 0.79 | BCL2 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563735-B2 | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20100152183-A1 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-17 | — | — | US | disclosed |